Breast Cancer Metastasis To Liver


When Can Metastatic Breast Cancer Occur

Ones For Wellness: Metastatic Breast Cancer

Some people have metastatic breast cancer when they are first diagnosed with breast cancer . This is called de novo metastatic breast cancer.

Most often, metastatic breast cancer arises years after a person has completed treatment for early or locally advanced breast cancer. This may be called a distant recurrence.

A diagnosis of metastatic breast cancer is not your fault. You did nothing to cause the cancer to spread.

Metastatic breast cancers come from breast cancer cells that remained in the body after treatment for early breast cancer. The breast cancer cells were always there but were dormant and could not be detected. For some unknown reason, the cancer cells began to grow again. This process is not well-understood.

Breast Cancer Subtypes Hormonal And Her2 Status

Although the term breast cancer is used in general, there are many different sub-types of breast cancers. The sub-types behave in different ways, with some responding better to treatments and some growing and spreading at faster rates.

Obviously, the sub-type of breast cancer affects survival rates.

There are 5 molecular types of breast cancer:-

  • Luminal A: This type of breast cancer is hormone receptor-positive and HER2 negative. Furthermore, Luminal A cancers tend to be low-grade and slow growing. These tumors respond well to hormone therapy.
  • Luminal B: These tumors are ER+ and can be HER+ or HER-. Luminal B cancers tend to grow faster, be of a higher grade and larger tumor size.
  • Triple negative/basal-like. As the name suggests these tumors are ER- PR- and HER-. Triple-negative breast cancers have a poorer prognosis and do not respond as well to treatment.
  • HER2-enriched: ER- PR- and HER2 positive. These tumors used to have a poor prognosis but since targeted therapy survival rates have improved.
  • Normal-like: These cancers are hormone receptor positive and HER2 negative. Normal-like breast cancers have a good prognosis.
  • Risks/chances Of Breast Cancer Metastasis To Liver

    There are a slight number of cases early in cancer diagnosis that already have breast cancer metastasis to the liver. The number totals around less than 5 percent of all breast cancer diagnoses. In cases of early breast cancer that is still only in breast tissue, risk increases depending on the person, health status, and time after cancer treatment.

    If you have been diagnosed with breast cancer metastases, there will be some increased challenges in treating and slowing the progression. It depends on the stage of cancer, the treatment, and time since diagnosis.

    Metastasis occurs when the cancer has spread to the lymph nodes and hitches a ride into other organs. At first, the cancer goes into the lymph nodes near the armpit “axillary lymph nodes.” At this stage, there is a possibility of curing the cancer. If the cancer moves beyond the axillary lymph nodes, there is no cure but it is treatable.

    Path of Breast Cancer Spreading to the Liver

    Breast cancer spreading into your liver takes a certain path in stages. These are:

    • Invasion of Local Tissue

    The cancer cells invade the local breast tissue and form tumors. The cells then grow into tissue around the breasts. It begins to take over all the healthy tissue in the area. The cancer moves outside of the breast tissue or “margins.”

    • Lymph Node Invasion

    After entering the lymph nodes, the cancer then invades the circulation and travels through the bloodstream to distant organs. This can include the lungs, liver, brain, and bones.

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    Whats The Outlook For Metastatic Breast Cancer

    The right treatment plan can improve survival for people with metastatic breast cancer. However, survival rates vary and are dependent on a number of factors including type/biology of the breast cancer, parts of the body involved and individual characteristics. About 1 in 3 women live at least five years after diagnosis. Some live 10 years or longer. Your care team will discuss your prognosis with you in more detail.

    What Causes Breast Cancer To Metastasize Or Spread

    Metastatic Breast Cancer To Liver

    With any type of solid tumor like breast cancer, theres a chance that cancer cells will break free from the original tumor. These cells can circulate in the bloodstream or lymphatic system, which filters out bacteria and viruses.

    These free-floating cancer cells move through the body, eventually settling in new locations. There, they start to multiply and form new cancer tumors. More than half of people with breast cancer develop bone metastases . But cancer cells can also settle in organs. The liver is the third most common site for breast cancer metastases.

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    What About The Management Of Extrahepatic Metastases

    We have seen that LMBC is frequently associated with EHM because of their similar routes of dissemination. The survival data on EHM are contradictory, and 4 authors have specifically studied this prognostic factor without demonstrating any statistical correlation with survival.38, 40, 47, 53 Conversely, other surgical series have reported shorter OS in the case of EHM, most frequently under univariate analysis only . As described in our series,38 patients harboring extrahepatic

    Newly Diagnosed Or Worried About A Symptom

    In the days or weeks after a diagnosis of secondary breast cancer, you may feel in turmoil and find it hard to think clearly.

    You can read our information for people newly diagnosed with secondary breast cancer, including where to find support.

    If you havent been diagnosed but are worried about a symptom, find out more about the signs and symptoms of secondary breast cancer.

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    When Do People Get A Metastatic Breast Cancer Diagnosis

    Metastatic breast cancer can occur at different points:

    • De novo metastatic breast cancer: About 6% of women and 9% of men have metastatic breast cancer when theyre first diagnosed with breast cancer.
    • Distant recurrence: Most commonly, metastatic breast cancer is diagnosed after the original breast cancer treatment. A recurrence refers to the cancer coming back and spreading to a different part of the body, which can happen even years after the original diagnosis and treatment.

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    Exercise And Secondary Breast Cancer In The Liver

    Surgery Liver Secondaries Metastasis to of Cancer spread

    Some people with secondary breast cancer in the liver have no symptoms while others have a combination of pain, sickness, loss of appetite, hiccups, tiredness and fatigue. While physical activity may help reduce some symptoms its important to listen to your body and not push yourself too hard. Gentle, regular activity, such as walking, is often most effective.

    If youre currently having treatment you may need to exercise at a slightly lower level. Stop straight away if it hurts or feels like youre working too hard.

    When choosing your exercise, try to focus on aerobic activities such as walking, swimming or cycling. Activities such as dancing and gardening can also be beneficial. You could also include some light toning or conditioning exercises such as stretching or low-impact yoga. The most important thing is to choose something you can safely enjoy.

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    Baseline Characteristics And The Incidence Of Liver Metastases

    A total of 311,573 patients from SEER database diagnosed between 2010 and 2016 were included in the present study. Of these patients, there were 15,884 MBC patients and 4067 BCLM patients at initial diagnosis . In the FUSCC dataset, there were 1728 of 3048 metastatic breast cancer patients had liver metastases during the follow-up . The consistent and inconsistent characteristics of two datasets were shown in Tables and . The baseline characteristics showed a higher proportion of patients with infiltrating duct carcinoma , extrahepatic metastases and HR+/HER2 subtype in the both SEER and FUSCC dataset. However, the differences between SEER and FUSCC were significant as well, such age, race, stage at initial diagnosis. The patients in the FUSCC dataset were younger and almost all of them were Asian patients, different from those in the SERR database. Most notably, the majority of FUSCC patients were recurrent breast cancer who underwent curative resection for primary tumors while all patients from the SEER database were diagnosed with de novo metastatic breast cancer.

    Table 1 Baseline characteristics of breast cancer with liver metastases at diagnosis in the SEER database

    Definition Of Metastatic Breast Cancer

    Here we will know the definition of metastatic breast cancer to know metastatic breast cancer vs. breast cancer. Metastasis is the process of cancer cells spreading. It is cancer spreading from the breast to another body part, like breast cancer in the liver, lungs, brain, or bones. It occurs when the breast cancer cells break down the breast tumor and move through the body in the lymph system or the bloodstream.

    Metastasis also happens when cancer cells break away from the original breast tumor to other body parts. These cancer cells also travel through the lymphatic system or the bloodstream

    Breast cancer can return to another body part after months or years after the initial diagnosis and treatment. It is called distant recurrence or metastatic recurrence. Around 30% of the diagnosed women with early-stage breast cancer also develop metastatic disease. As there are only some male breast cancer cases, it is not clear how many metastasize, but men can also get a diagnosis of metastatic breast cancer.

    After the initial breast cancer diagnosis is metastatic, it is known as De Novo metastatic breast cancer. It means that by the time breast cancer is initially diagnosed, it has already reached other areas of the body.

    The metastatic cancer cells consist of cells from the initial tumor site made up in the breast. So, after the breast cancer starts spreading towards the bones, the bone region metastatic tumor will not have bone cancer cells but breast cancer cells.

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    What You Need To Know

    • Metastatic breast cancer is serious, but the diagnosis does not always mean the end of life.
    • The most common place for breast cancer to spread is to the bones. The liver and the lungs are other areas where breast cancer can metastasize.
    • In about 15% of cases, metastatic breast cancer can be detected at the time of diagnosis. It can affect people who had breast cancer without seeking treatments, patients with aggressive breast cancer types and those with breast cancer not detected by screening.

    Stage 4 Liver Cancer Treatment Options


    Once liver cancer spreads and becomes metastatic, it can no longer be treated with surgery because the disease has become so widespread. Instead, chemoembolization, a form of chemotherapy, may be a recommended course of treatment. Targeted therapy may be an option to help slow the tumor’s growth. The patient’s oncologist will likely also offer therapies focused on easing the symptoms often associated with liver cancer, such as pain, appetite loss and nausea.

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    The Role Of Caregivers

    Caregivers also play a vital role in helping a person with cancer be as comfortable as possible. To help, a caregiver can:

    According to the American Society for Clinical Oncology, in 2018, doctors will diagnose invasive breast cancer in an estimated 268,670 people in the United States.

    The ACS state that the 5-year relative survival rate for people with metastatic breast cancer is around 22 percent. This means that people with metastatic breast cancer are 22 percent as likely as people without the condition to live at least 5 years following diagnosis.

    However, many factors can affect how long a person with metastatic breast cancer lives for, including:

    • the type of breast cancer
    • the stage of breast cancer
    • where the cancer has spread to
    • how well the cancer responds to treatment
    • any other health issues that the person has

    Everyoneâs outlook is different. It is also important to note that survivals rates are just estimates, and that doctors base these figures on data from at least 5 years ago. Continuing advancements in cancer treatments means that survival rates are improving.

    A Prognostic Model For Breast Cancer With Liver Metastasis

    • 1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China
    • 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    • 3Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

    Background: Breast cancer with liver metastasis consists of a group of heterogeneous diseases, and survival time may be significantly different, ranging from a few months to several years. The present study aimed to develop and externally validate a prognostic model for breast cancer with liver metastasis .

    Methods: In total, 1022 eligible patients from January 2007 to December 2018 were selected from Fudan University Shanghai Cancer Center and were temporally in the training and validation set. According to regression coefficients found in the multivariate Cox regression analysis, the final results were transformed into the prognostic scores. On the basis of these scores, patients were finally classified into three risk groups, including low-, intermediate-, and high-risk groups. Bootstrapping was used for internal validation. Then, time-dependent receiver operating characteristic curves and calibration plots were used to assess discrimination and calibration of this prognostic model in the validation set.

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    How Do Breast Cancers Spread

    Cancer cells break away from the primary tumor, entering the bloodstream or the lymphatic system. As large vessels narrow, cancer cells stop traveling and lodge themselves in a new area. Then they begin dividing and moving into surrounding tissue. The cancer cells take over the new area, crowding out healthy cells and forming a new tumor. Cancer cells are insidious because the new tumor can set up its own network of blood vessels to obtain nutrients for growth and further spread.

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    A Disease No One Gets

    Cancer Metastasis in the Liver – All Symptoms

    Sadly, people donât âgetâ mets. In fact, a recent survey sponsored by Pfizer Oncology shows just how misunderstood it is. Sixty percent of the 2,000 people surveyed knew little to nothing about MBC while 72 percent believed advanced breast cancer was curable as long as it was diagnosed early. Even more disheartening, a full 50 percent thought breast cancer progressed because patients either didnât take the right treatment or the right preventive measures.

    âTheyâve built an industry built on four words â early detection equals cure â and that doesnât even begin to define breast cancer,â said Schoger, who helped foundBreast Cancer Social Media, a virtual community for breast cancer patients, caregivers, surgeons, oncologists and others. âWomen are blamed for the fate of bad biology.â

    The MBC Alliance, a consortium of 29 cancer organizations including the biggest names in breast cancer , addressed this lack of understanding and support as well as what many patient advocates term the underfunding of MBC research in a recently published landmark report.

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    When Breast Cancer Spreads To The Liver

    Posted: Feb 23, 2021, 7:00:00 AM

    Breast cancer can spread months or even years after you stop cancer treatments. Its estimated that 1 in 3 women with breast cancer eventually develops metastatic breast cancer. The condition also affects men with breast cancer. Metastatic breast cancer is also known as stage 4 or advanced breast cancer.

    Changes In Hormonal Receptor Status And Her

    ER, PR, and HER-2 status is essential in determining the use and evaluating the effect of adjuvant hormone therapy, molecular targeted therapy, and even chemotherapy. Koo et al. conducted a study to assess the status of ER, PR, and HER-2 in primary and metastatic breast cancers and determined the relationship between ER, PR, and HER-2 and organ-specific metastases of breast cancer. The data showed that ER+ or PR+/HER-2- subtypes were predominant in the sites of liver metastases . Increased phosphorylation of HER-2 appears to be extremely important for the establishment of breast cancer liver metastases . Moreover, a high serum HER2 level or lack of ERs independently doubles the relative risk of progression and mortality .

    Nevertheless, the ER, PR, and HER-2 status between primary breast cancers and liver metastatic foci can be changed after treatment, but are stable in most cases during the liver metastatic process . Botteri et al. conducted a retrospective study of patients with BCLM and found a positive relationship between liver biopsy findings and survival in patients with early metastases. Moreover, another study showed that biopsies of metastases are useful for the reassessment of the metastatic sites to define a more effective treatment strategy for patients with BCLM . Thus, the ER, PR, and HER-2 status needs to be reassessed by biopsy when liver metastases occur.

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    Role Of Sinusoidal Capillaries

    Previous studies have reported that the initial arrest of cancer cells in the sinusoids of the liver is restricted by the sizes of cancer cells . Haier et al. has determined that tumor cells adhere to sinusoidal capillaries, the internal diameter of which is larger than the tumor cells. Unique structural features of liver, including the existence of a fenestrated endothelium and lack of an organized sub-endothelial basement membrane, have a great impact on the interactions between breast cancer cells and the liver microenvironment. Of great interest, the fenestrated endothelium controls liver-specific microvascular exchange and impacts the ability of cells to transmigrate through the vessels into the liver . Moreover, previous studies have revealed that breast cancer cells extend cellular projections through the fenestrated endothelium into the space of Disse on seeding the liver, which makes direct contact with hepatocytes . In addition, Martin et al. has found that breast cancer cells are bound to vessels with clear vascular labeling in the sites of liver metastases. Thus, sinusoidal capillaries play a significant role in the initial arrest of breast cancer.

    What Is Metastatic Breast Cancer

    Metastatic Breast Cancer To Liver

    Metastatic breast cancer is the most advanced stage of breast cancer. Breast cancer develops when abnormal cells in the breast start to divide uncontrollably. A tumor is a mass or collection of these abnormal cells.

    Metastasis refers to cancer cells that have spread to a new area of the body. In metastatic breast cancer, cells may spread to the:

    Healthcare providers name cancer based on its primary origin. That means breast cancer that spreads to other body parts is still considered breast cancer. The cancer cells are still breast cancer cells. Your care team will use breast cancer therapies, even if the cancer cells are in other areas.

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