Life Expectancy After Liver Resection


Survival Statistics For Liver Cancer

What Is Life Like After Liver Transplant?

Survival statistics for liver cancer are very general estimates and must be interpreted very carefully. Because these statistics are based on the experience of groups of people, they cannot be used to predict a particular person’s chances of survival.

There are many different ways to measure and report cancer survival statistics. Your doctor can explain these statistics and what they mean to you.

What To Expect After A Liver Resection

A liver resection is a surgery to remove part of a patients liver. The liver is unique among all the interior organs in the human body in that it is capable of regenerating, meaning as much as 50 per cent of the liver can be removed during a resection so long as the other half is healthy, the organ will regenerate over time.

Measurement Of Study Variables

Patient characteristics

Subjects were categorised by age group at diagnosis, year of diagnosis, race/ethnicity, gender, marital status, number of positive lymph nodes of primary colorectal cancer, tumour grade of primary cancer, comorbidity score, residence , the type of hospital in which they received care and the socioeconomic status of their census tract/zip code. We obtained data on age, race, gender, marital status, surgery, stage, tumour grade, lymph nodes, type of hospital, and area of residence from the SEER database, NCI Hospital file, and AMA files, and data on comorbid conditions and treatment from Medicare.

We generated an aggregate SES score from a hierarchy of income data from the 2000 census. Patients were ranked on a 15 scale, with 1 as the lowest value, based on a formula incorporating as many of the following as were available: median income in the census tract of residence, median income in the zip code of residence, census tract per capita income, zip code per capita income patients for whom all of these values were missing were assigned to the lowest SES category.

Treatment characteristics

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Getting Ready For Liver Resection Surgery

Before your operation, youll likely undergo imaging to determine the size and location of the tumor, and to see whether cancer also exists outside the liver. Computed tomography scans or magnetic resonance imaging scans with contrast may be used, in addition to other tests. A CT scan may also be used to estimate the size and volume of the portion of the liver that would be left after surgery.

If the portion of the liver that would remain after a resection is deemed too small, doctors can utilize a technique to wither the cancer-bearing area while stimulating the remainder to rapidly grow. The technique, called portal vein embolization, blocks blood supply to the part of the liver with cancer. For some patients, results occur within three to four weeks. For those with diabetes or cirrhosis, an additional three to four weeks may be needed.

A short course of chemotherapy may be administered before surgery, as long courses may injure the liver. Chemotherapy may also be used for patients with metastatic tumors on both sides of the liver who undergo a two-stage hepatectomy. In those cases, a short course of chemotherapy is given, followed by a limited resection of the side of the liver with less cancer. Blood supply to the other side is then blocked to promote growth of the resected side. After recovery, a larger resection of the more affected side of the liver is performed.

Clinicopathologic Features Of The 10

Liver Cancer Life Expectancy Chart

Table âTable44 shows the clinicopathologic features of the 10-year recurrence-free survivors . Of these 7 patients, 6 patients were still alive on the date when the study was censored and 1 patient died of cardiovascular disease. Six patients were males. All the 7 survivors had Child-Pugh grade A liver function and they had no cirrhosis. Four of these 7 patients were HBsAg positive. Histopathological examination showed that all the 7 patients had a solitary moderately differentiated tumor with a diameter which ranged from 2.0 to 5.0 cm. There were no evidences of nodal metastasis or local extrahepatic invasion in these 7 patients.

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What Are The Risks Or Complications Of Liver Resection Surgery

Complications may include:

  • Infection. You can get an infection in your incision wound, your urinary tract or your lungs . Your provider treats such infections with antibiotics.
  • Bleeding. Your liver has a lot of blood vessels, and its also responsible for making your blood clot stop bleeding. Liver surgery interferes with this process, so sometimes patients bleed too much. Some may need a blood transfusion after surgery.
  • Bile leakage. Damage to any of the bile ducts in your liver during surgery can cause bile to leak, which may collect inside your abdomen. This may require placing an additional drain.
  • Pleural effusion. After liver surgery, fluid can easily build up inside your chest cage. It can cause chest pain and shortness of breath. It may be treated with medication or may need to be drained.
  • Ascites. Liver surgery can also cause a buildup of fluid in your abdominal cavity. It may be treated with medication or may need to be drained.
  • Deep vein thrombosis. After any surgery, theres a risk of blood clots from being in bed for a long time. Pay attention to any spot on your arms or legs that seems swollen or sore.
  • Kidney failure. Sometimes surgery can cause your kidneys to stop working. It is important to stay well hydrated.
  • Liver failure. If the remaining liver doesnt have enough function left, you can go into liver failure. In this case, you may need an urgent liver transplant.

Survival Rates For Liver Cancer After Resection

More than 42,000 Americans are expected to be diagnosed with primary liver cancer in 2021, according to the American Society of Clinical Oncology, and more than 30,000 are estimated to die. Men are about three times more likely than women to face this diagnosis.

Of the primary liver cancers, hepatocellular carcinoma is the most common. Other forms include intrahepatic cholangiocarcinoma , angiosarcoma and hemangiosarcoma , and hepatoblastoma .

Most tumors found in the liver spread from cancer elsewhere in your body. This is called metastatic or secondary liver cancer. While these may originate from many sources, such as the lungs, breasts, pancreas or stomach, most result from colorectal cancer. About 30 percent of colorectal cancer patients develop metastatic tumors in their liver, according to a review in the journal Anticancer Research.

For people with colorectal cancer that has spread to the liver, the five-year survival rate after resection has been estimated at 25 percent to 40 percent, according to a study in International Scholarly Research Notices. This contrasts with a five-year survival rate of less than 2 percent for people whose colorectal carcinoma spread to the liver but who didnt have a liver resection, according to a study in Surgical Treatment.

Estimates of life expectancy after a liver resection vary depending on the type of cancer, as well as other factors, such as how advanced the cancer is, your age, your general health and other treatments used.

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Assessment Of Study Quality

All included studies were assessed for quality using a validated checklist for methodological quality of non-randomized studies . The MINORS checklist contains 12 items for comparative studies and 8 items for non-comparative studies . A low score represents a high risk of bias, whereas a high score reflects a low risk of bias. None of the studies were excluded on the basis of their score. Baseline characteristics were assessed to determine whether selection bias or confounding by indication might have played a role.

Possible Risks And Side Effects

Life Expectancy After Liver Transplant – in Years

Liver resection is a major, serious operation that should only be done by skilled and experienced surgeons. Because people with liver cancer usually have other liver problems besides the cancer, surgeons have to remove enough of the liver to try to get all of the cancer, but also leave enough behind for the liver to function.

  • Bleeding: A lot of blood passes through the liver, and bleeding after surgery is a major concern. Also, the liver normally makes substances that help the blood clot. Damage to the liver can add to potential bleeding problems.
  • New liver cancer: Because the remaining liver still has the underlying disease that led to the cancer, sometimes a new liver cancer can develop afterward.

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What Happens When Part Of Your Liver Is Removed

Your liver has a remarkable ability to repair and regenerate itself. It wants to return to a consistent size thats proportional to your overall body size. When liver cells detect damage, they communicate with each other to begin dividing and replicating themselves until that size is reached. This process depends on healthy liver tissue, and some livers may be slower to regenerate or reach their former size.

Studies Comparing Patients Aged < 75 Years With Patients Aged > 75 Years

Patient Characteristics

Elderly patients represented 1014% of the study population in the respective studies. The weighted mean age of patients aged < 75 years was 61.5 ± 6.7 years, whereas the weighted mean age of patients aged > 75 years was 77.6 ± 1.6 years. Only 2 studies reported on comorbidity , which showed that patients aged > 75 years were affected more often by cardiovascular comorbidity . There was no difference in respiratory comorbidity and diabetes mellitus compared with patients aged < 75 years .

Details of Operations

The weighted mean operative time was 267 ± 104 min for patients aged < 75 years and 260 ± 108 min for patients aged > 75 years . Major hepatectomy was more frequently performed in patients aged < 75 years compared with patients aged > 75 years . Only 2 studies reported histopathological radicality , which showed no differences .

Postoperative Outcomes

Hospitalisation time varied widely between the respective studies from a mean hospital stay of 6 days to a mean hospital stay of 22 days. Weighted mean hospitalisation time was comparable for patients aged < 75 years with patients aged > 75 years .

Overall postoperative morbidity was reported by 3 studies . The weighted morbidity was 21% for patients aged < 75 years compared with 32% for patients aged > 75 years .

Fig. 3.

Long-Term Outcome

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What Is A Liver Resection

A liver resection, or hepatectomy, is a surgical procedure to remove part of your liver. You can have up to two-thirds of your liver removed as long as the rest of your liver is healthy. If you have liver disease, a smaller portion may be removed. Your liver can grow back. If your remaining liver is healthy, itll grow back to its former size.

What Is The Difference Between Laparoscopic/robotic Vs Open Hepatectomy

Hepatitis B Liver Transplant Survival Rates

In open abdominal surgery, one long incision called a laparotomy opens up your abdominal cavity. Surgeons are able to visualize your abdomen directly. Its best suited for more complex procedures.

In laparoscopic surgery, the entire operation takes place through small keyhole incisions while your surgeon looks at the images from the camera on a screen. They use specially designed, long instruments to complete your liver resection. They can also use robotic arms. Movement is somewhat restricted, so surgeons traditionally use a laparoscopic or robotic approach for less complex liver resections. But with the development of surgical techniques, more complex surgeries such as major liver resection or living donor liver resections are now possible through a laparoscopic or robotic approach.

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Coping With A Diagnosis

According to the VA, although cirrhosis is progressive, some people with the condition can move from decompensated, or symptomatic, back to the asymptomatic stage. This is a challenging process, although one of the critical steps is avoiding alcohol of any kind.

To prevent progressing from the asymptomatic to the symptomatic stage, people can make the following lifestyle changes:

  • exercising regularly
  • keeping to a moderate weight
  • getting treatment for conditions that might have caused cirrhosis, such as hepatitis C or B
  • getting regular check-ups and prompt treatment for complications
  • quitting smoking

Of people who develop cirrhosis, 2060% also develop malnutrition, additional complications, longer hospital stays, and a reduced life expectancy.

This means eating a healthful diet is crucial for those with this condition. Cirrhosis itself can affect diet and metabolism, so people should try:

  • consuming a low-salt diet
  • avoiding too much vitamin A and D
  • avoiding taking vitamin C, if iron levels are high

Life Expectancy For Liver Metastases

The life expectancy for secondary liver cancer or liver metastases depends upon the extent of spread of the primary cancer. Its spread or cure does not have a fixed time frame hence, it would be misleading to give you an exact statistic.

The life expectancy for secondary liver cancer or liver metastases depends upon the extent of spread of the primary cancer. Its spread or cure does not have a fixed time frame hence, it would be misleading to give you an exact statistic.

Secondary liver cancer, which is also called liver metastasis, occurs when cancer spreads from the primary site to the liver. It originates either in the colon, breast, lung, pancreas, or the gastrointestinal tract of the person. This implies that the symptoms of cancer first develop in one of the aforementioned organs, and then it spreads to the liver.

Prognosis of cancer that has originated somewhere else and has invaded liver as it has reached the advanced stage can be made after performing various diagnostic tests like an ultrasonography, spiral CT scan with contrast and/or an MRI scan with contrast. The prognosis varies according to each individual. To decide the course of the treatment, it is necessary to know the type and stage of the cancer.

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What Does Life After Liver Resection Surgery Look Like

Youll be sore and tired for a while. You may also feel sick to your stomach at first. These symptoms should begin to ease in the first two weeks. In the meantime, take it easy.

Your healthcare provider will give you instructions about how to care for your incision as it heals. Theyll also tell you when its safe to bathe and have sex again. Youll need to avoid alcohol to protect your recovering liver.

Definition Of Bclc Stage And Resectable Hcc

Life reset after liver re-transplantation

The BCLC stage is described as follows. Stage 0 includes single tumors smaller than 2 cm in diameter. Stage A includes single tumors smaller than 5 cm in diameter or up to three tumors all smaller than 3 cm in diameter. Stage B includes up to three tumors or more than three tumors of any size. Single tumors exceeding 5 cm in diameter are included in this stage based on the article by Bruix and Llovet. Stage C includes macrovascular invasion . Alternatively, stage C involves lymph node metastases or distant metastases. Resectable HCC consists of Child-Pugh stages A and B patients with any size single resectable tumor or multifocal tumor which was defined as two to three tumors exceeding 3 cm in maximal diameter, in the absence of cancer-related symptoms, main trunk of portal vein invasion, and/or extra-hepatic spread .

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Efficacy Of Liver Resection For Single Large Hepatocellular Carcinoma In Child

  • Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea

Background: Therapeutic strategies and good prognostic factors are important for patients with single large hepatocellular carcinoma . This retrospective study aimed to identify the prognostic factors in patients with single large HCC with good performance status and Child-Pugh A cirrhosis using a large national cancer registry database and to recommend therapeutic strategies.

Methods: Among 12139 HCC patients registered at the Korean Primary Liver Cancer Registry between 2008 and 2015, single large HCC patients with Eastern Cooperative Oncology Group performance status 0 and Child-Pugh score A were selected.

Results: Overall, 466 patients were analyzed. The 1-,2-,3-, and 5-year survival rates after initial treatment were 84.9%, 71.0%, 60.1%, and 51.6%, respectively, and progression-free survival rates were 43.6%, 33.0%, 29.0%, and 26.8%, respectively. Platelet count < 100 × 109/L , sodium level < 135 mmol/L , maximum tumor diameter 10 cm , and treatment other than resection were significantly associated with poorer overall survival sodium < 135 mmol/L , maximum tumor diameter 10 cm , and treatment other than resection were independently associated with poorer progression-free survival.

Factors Affecting Overall Survival And Progression

Univariate analysis showed that the Child-Pugh score, MELD score, platelet count, total bilirubin, serum albumin, sodium, maximum tumor diameter, and initial treatment modality were associated with survival rate . Among these factors, platelet count < 100 × 109/L , sodium level < 135 mmol/L , maximum tumor diameter 10 cm , and treatment other than resection were significantly associated with poorer overall survival.

Table 2 Univariate and multivariate analyses of factors affecting overall survival and progression-free survival.

Figure 3 Kaplan-Meier analysis of survival according to initial treatment modality. Overall survival, progression-free survival.

Another univariate analysis identified that hepatitis C virus infection as an underlying liver disease , Child-Pugh score 6 , platelet count < 100 × 109/L , serum albumin < 3.5 g/dL , sodium level < 135 mmol/L , PIVKA-II level 1000 mAU/mL , maximum tumor diameter 10 cm , and initial treatment other than resection were associated with poorer progression-free survival after initial treatment. Multivariate analysis revealed that sodium < 135 mmol/L , maximum tumor diameter 10 cm , and treatment other than resection were independently associated with poorer progression-free survival.

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What Are The Results Of Liver Resection

  • For HCC patients whose tumors are successfully resected, the five-year survival is about 10% to 60%, depending on the tumor size and type.
  • This means that 10% to 60% of patients who actually undergo liver resection for liver cancer are expected to live five years.
  • Many of these patients, however, will have a recurrence of liver cancer elsewhere in the liver.
  • Moreover, it should be noted that the survival rate of untreated patients with similar-sized tumors and similar liver function is probably comparable.
  • Some studies from Europe and Japan have shown that survival rates with alcohol injection or radiofrequency ablation procedures are comparable to the survival rates of those patients who underwent resection.
  • But again, the reader should be cautioned that there are no head-to-head comparisons of these procedures versus resection.

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Medically Reviewed on 1/27/2021

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