Pancreatic Cancer Incidence By Age

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Rates Of Pancreatic Cancer Incidence And Mortality Increase With Age

Pancreatic Cancer Rates Continue to Rise

Typical of many types of cancer, the rate of diagnosis of pancreatic cancer increases with age. Pancreatic cancer is very rare at the youngest ages. From 2011 to 2013, new cases identified prior to the age of 35 were diagnosed at a rate of 0.2 per 100,000 persons in Canada and accounted for 0.5% of all pancreatic cancers . However, the incidence rate of this cancer increased from 1.3 per 100,000 among those aged 35 to 39 at diagnosis to 87.2 per 100,000 among those 90 and older . The largest absolute increase in incidence rates from one age group to the next occurred between the 65-to-69 and 70-to-74 age groups. More generally, the largest increases occurred between the ages of 55 and 84.

Age-specific pancreatic cancer incidence and mortality rates, by age group, ages 35 and older, Canada, 2011 to 2013Table summary This table displays the results of Age-specific pancreatic cancer incidence and mortality rates. The information is grouped by Age group , Rate, 95% Lower Limit and 95% upper limit, calculated using rate units of measure .

Age group
Note: 95% confidence intervals are denoted by vertical bars overlaid on the trend lines. They indicate the degree of variability in the estimates. Rates are based on counts that have been randomly rounded to a base of five. Statistics Canada, Canadian Cancer Registry and Canadian Vital Statistics Death Database.

What Is A 5

A relative survival rate compares people with the same type and stage of pancreatic cancer to people in the overall population. For example, if the 5-year relative survival rate for a specific stage of pancreatic cancer is 50%, it means that people who have that cancer are, on average, about 50% as likely as people who dont have that cancer to live for at least 5 years after being diagnosed.

Age Of Diagnosis Influences Risk Factors In Pancreatic Cancer

In an interview with Targeted Oncology, Chen Yuan, MD, further discussed the research on the age-dependent associations and risks for patients with pancreatic cancer.

Risk factors deemed to be inherited or lifestyle-associated risk factors strongly correlate with earlier-onset pancreatic cancer and show the importance of age at initiation to prevent cancer and control programs targeting this malignancy.

While more than 80% of patients with pancreatic cancer have it present as advanced disease, experts are unaware of the appropriate ages to consider for prevention and early detection strategies.

A study led by Chen Yuan, MD, observed a total of 167,483 participants from 2 prospective cohort studies in the United States with 1190 incident cases of pancreatic cancer during more than 30 years of follow-up were included in the trial. There were 5,107 cases of pancreatic cancer, 8,845 participants in the control arm of a completed multicenter genome-wide association study, and 248,893 pancreatic cancer cases which were documented in the United States Surveillance, Epidemiology, and End Results Program.

Investigators looked at multiple lifestyle factors they thought may influence earlier-onset pancreatic cancer, including cigarette smoking, obesity, diabetes, height, and non-O blood group. The main goal of the study was to evaluate the risk of developing pancreatic cancer by age.

Can you discuss what was investigated in the study?

Reference:

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What Causes Pancreatic Cancer

There is evidence that the following are associated with an increased risk of pancreatic cancer: smoking and family history, particularly where more than one family member is involved.

There is also strong evidence that:

There is some evidence that:

  • consumption of red meat might increase the risk of pancreatic cancer
  • consumption of processed meat might increase the risk of pancreatic cancer
  • consumption of foods containing saturated fatty acids might increase the risk of pancreatic cancer
  • consumption of alcoholic drinks might increase the risk of pancreatic cancer
  • consumption of foods and beverages containing fructose might increase the risk of pancreatic cancer

Notes

The data on this page comes from the Global Cancer Observatory, owned by the World Health Organization/International Agency for Research on Cancer, and is used with permission. The cancer incidence figures and ASRs were compiled using the data available here . For queries about our cancer statistics please email the Research Interpretation team: .

Recent Irrs By Racial/ethnic Group

The Statistics on Pancreatic Cancer

Among residents of the SEER 18 during 200013, Black males and females had higher pancreatic cancer rates compared with those who were White non-Hispanic . In contrast, compared with those identified as White non-Hispanic, rates were lower among Asian/Pacific Islander residents , White Hispanic males and American Indian/Alaskan Native males . The rates among White non-Hispanic and White Hispanic females were similar.

Pancreatic cancer counts, rates, and incidence rate ratios by gender and racial/ethnic group, SEER 18 1

Total pancreas .

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Survival Decreases With Age

For those diagnosed with pancreatic cancerNote 12 from 2005 to 2007 the one-year net survival was highest in the youngest age group and then declined with each successive age group . Among those diagnosed between the ages of 15 and 44, the one-year net survival was 48.7%. In contrast, the lowest one-year, age-specific net survival, 11.2%, was for people who were aged 85 to 99 at diagnosis.

One-year cumulative pancreatic cancer net survival, by age group, ages 15 to 99, Canada excluding Quebec, 2005 to 2007Table summary This table displays the results of One-year cumulative pancreatic cancer net survival. The information is grouped by Time since diagnosis , Net, 95% lower limit and 95% upper limit, calculated using net survival units of measure .

Time since diagnosis
Note: 95% confidence intervals are denoted by vertical bars overlaid on the trend lines. They indicate the degree of variability in the estimates.Statistics Canada, Canadian Cancer Registry and life tables.

Median Survival Time Short

A complimentary outcome measure which helps to summarize the severity and prognosis of pancreatic cancer is the median survival time. For those diagnosed with pancreatic cancerNote 12 from 2005 to 2007, the median survival time from any cause of death was 3.9 months, or just under 17 weeks . In other words, one half of those diagnosed with pancreatic cancer during this period were alive approximately 3.9 months later, while one half died some time before then. It is important to keep in mind that this estimate is based on a large group of people with varying circumstances.Note 13 One important consideration is age at diagnosis.

Pancreatic cancer median survival time, by age group, ages 15 to 99, Canada excluding Quebec, 2005 to 2007Table summary This table displays the results of Pancreatic cancer median survival time. The information is grouped by Age group , Median survival, 95% lower limit and 95% upper limit, calculated using median survival units of measure .

Age group
Note: Horizontal bar indicates the median survival time for ages 15 to 99 combined. 95% confidence intervals are denoted by vertical lines overlaid on the bars. They indicate the degree of variability in the estimates. Statistics Canada, Canadian Cancer Registry.

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How Common Is Pancreatic Cancer

The American Cancer Societys estimates for pancreatic cancer in the United States for 2022 are:

  • About 62,210 people will be diagnosed with pancreatic cancer.
  • About 49,830 people will die of pancreatic cancer.

Pancreatic cancer accounts for about 3% of all cancers in the US and about 7% of all cancer deaths.

It is slightly more common in men than in women.

Pancreatic Cancer Incidence By Sex And Uk Country

The oral microbiome, pancreatic cancer, and human diversity in the age of precision medicine

Pancreatic cancer is the 10th most common cancer in the UK, accounting for 3% of all new cancer cases .

In females in the UK, pancreatic cancer is the 9th most common cancer . In males in the UK, it is the 12th most common cancer .

48% of pancreatic cancer cases in the UK are in females, and 52% are in males.

Pancreatic cancer incidence rates rate ) for persons are significantly lower than the UK average in Scotland and similar to the UK average in all other UK constituent countries.

For pancreatic cancer, like most cancer types, differences between countries largely reflect risk factor prevalence in years past.

Pancreatic Cancer , Average Number of New Cases Per Year, Crude and European Age-Standardised Incidence Rates per 100,000 Population, UK, 2016-2018

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Who Dies From This Cancer

Because survival is poor, the population distribution of people who die of pancreatic cancer is similar to that of people who are diagnosed with the disease. In part because it is difficult to detect early, the average survival time from pancreatic cancer is low. Pancreatic cancer is the third leading cause of cancer death in the United States. The death rate was 11.1 per 100,000 men and women per year based on 20162020 deaths, age-adjusted.

Death Rate per 100,000 Persons by Race/Ethnicity & Sex: Pancreatic Cancer

Males

Introduction: To Year 2022 Pancreatic Cancer Stats

Its important to note that the following pancreatic cancer stats represent a relative average of survival and death rates. Each pancreatic cancer patient is uniquely different and what treatment options perform best for each patient and respective responses and results will vary per patient depending upon many factors.

The earlier pancreatic cancer is diagnosed, the better the prognosis. Unfortunately, pancreatic cancer usually shows few impressive signs and symptoms, if any at all until the cancer has already advanced to later stages beyond the pancreas when surgical removal of the cancerous tumor is no longer possible. It becomes more progressively more difficult to treat which leads to greater mortality rates.

The following statistics mostly refer to Pancreatic Adenocarcinoma Cancer, the most deadly type of pancreatic cancer that occurs in the exocrine function of the pancreas which produces digestive enzymes. It accounts for over 90% of all pancreas cancers and is very aggressive, difficult to treat and accounts for the greatest mortality rate.

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Rate Of Diagnosis Consistently Higher In Males

Age-specific incidence rates of pancreatic cancer were consistently higher among males than females in Canada during the period from 2011 to 2013 . While rates increased with age for both sexes, they tended to do so at a slightly faster absolute pace among males. As such, the largest sex-specific difference in age-specific incidence rates occurred in the oldest age group . Relatively speaking, age-specific rates were generally 20% to 30% higher in males than females.

Age-specific pancreatic cancer incidence rates, by sex and age group, ages 35 and older, Canada, 2011 to 2013Table summary This table displays the results of Age-specific pancreatic cancer incidence rates. The information is grouped by Age group , rate, 95% lower limit and 95% upper limit, calculated using rate units of measure .

Age group
Note: 95% confidence intervals are denoted by vertical bars overlaid on the trend lines. They indicate the degree of variability in the estimates. Rates are based on counts that have been randomly rounded to a base of five. Statistics Canada, Canadian Cancer Registry and Canadian Vital Statistics Death Database.

Recent Rates And Male

Pancreatic Cancer

During 200013, there were 138597 cases of pancreatic cancer diagnosed among residents of the SEER 18 considerably more than the 95412 diagnosed among residents of the SEER 13 during the same time period . Despite the larger number of cases among females, rates were higher among males . Rates among males compared with females were higher among those aged 35 and older in contrast, rates among women were higher among those younger than age 35 . Most cancers were specified only as adenocarcinoma, NOS , for which males had an excess . About 15% of pancreatic cancers were ductal adenocarcinomas, with the IRR slightly higher for those specified as arising from an IPMN and slightly lower for those specified as mucinous. In contrast, there was a female excess for ductal adenocarcinoma specified as cystic . About 20% of the cancers were of endocrine origin, and the IRR was higher for non-secretory cancers than for the secretory cancers and intermediate for the carcinoids . Among the rare other specified adenocarcinoma types, rates among males were elevated for acinar cell adenocarcinoma and lower for solid pseudopapillary adenocarcinomas .

Pancreatic cancer counts, rates, and male/female incidence rate ratios overall, by age group and histologic type, SEER 18 1

.

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Incidence Of Pancreatic Cancer In The United States By Age And Sex 20002018

11/16/2021 12:40:51 PM

In a study reported in a research letter in JAMA, Gaddam et al found that the incidence of pancreatic cancer has increased in both men and women between 2000 and 2018, with a greater relative increase being observed in younger women.

Pancreatic cancer incidence rates per 100,000 population for 20002018 were obtained from the Surveillance, Epidemiology, and End Results database. Average annual percentage changes in incidence were calculated. Significance levels were P < .05 for the overall population and, to adjust for multiple comparisons, P < .025 for analyses of < 55 year and 55 year age groups and P < .0125 for analyses of 15 to 34 and 35 to 54 year age groups.

Key Findings

A total of 283,817 cases of pancreatic cancer were reported between 2000 and 2018. In the entire population, average annual percentage changes significantly increased in women and in men , with no significant between-group difference .

Among patients aged at least 55 years , average annual percentage changes significantly increased among women and men , with a significantly greater relative increase among men .

Among patients aged less than 55 years , average annual percentage changes significantly increased in women and men , with a significantly greater relative increase in women .

Among patients aged 35 to 54 years , average annual percentage changes increased significantly among women and men , with a significantly greater relative increase among women .

Availability Of Data And Materials

The datasets generated and/or analysed during the current study are provided in Table . Other non-public datasets, including genomic data, are not publicly available due to the non-public data should not be shared publicly as participants were informed at the time of providing consent that only researchers involved in the project would have access to the original information they provided for the protection of personal privacy and patients right as well as compliance with research ethics. Non-public data are available from the corresponding author under the approvals of patients and the Research Ethics Committee III of the China Medical University and Hospital.

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Latest Pancreatic Cancer Data

Pancreatic cancer is the 12th most common cancer worldwide. It is the 12th most common cancer in men and the 11th most common cancer in women. There were more than 495,000 new cases of pancreatic cancer in 2020.

The 10 countries with the highest rates of pancreatic cancer and the highest number of deaths from pancreatic cancer in 2020 are shown in the tables below.

ASR = age-standardised rates. These are a summary measure of the rate of disease that a population would have if it had a standard age structure. Standardisation is necessary when comparing populations that differ with respect to age because age has a powerful influence on the risk of dying from cancer.

Pancreatic Cancer Risk Factors

Why pancreatic cancer so deadly? Who’s most at risk?

A risk factor is anything that increases your chance of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a persons age or family history, cant be changed.

In some cases, there might be a factor that may decrease your risk of developing cancer or has an unclear effect. That is not considered a risk factor, but you may see them noted clearly on this page as well.

Having a risk factor, or even many, does not mean that you will get cancer. And some people who get cancer may have few or no known risk factors.

Here are some of the risk factors known to increase your risk for pancreatic cancer.

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Lifetime Risk Of Pancreatic Cancer

The average lifetime risk of pancreatic cancer is about 1 in 64. But each persons chances of getting this cancer can be affected by certain risk factors.

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

American Cancer Society. Facts & Figures 2022. American Cancer Society. Atlanta, Ga. 2022.

Lifetime Risk of Being Diagnosed with Cancer by Site and Race/Ethnicity: Both Sexes, 18 SEER Areas, 2013-2015 https://seer.cancer.gov/csr/1975_2015/results_merged/topic_lifetime_risk.pdf. Accessed on December 19, 2018.

Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA . SEER Cancer Statistics Review, 1975-2015, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2015/ based on November 2017 SEER data submission, posted to the SEER web site, April 2018. Accessed on December 19, 2018.

American Cancer Society. Facts & Figures 2022. American Cancer Society. Atlanta, Ga. 2022.

Lifetime Risk of Being Diagnosed with Cancer by Site and Race/Ethnicity: Both Sexes, 18 SEER Areas, 2013-2015 https://seer.cancer.gov/csr/1975_2015/results_merged/topic_lifetime_risk.pdf. Accessed on December 19, 2018.

Last Revised: January 21, 2022

American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.

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