Prognosis End Stage Liver Disease


Prognosis In Decompensated Chronic Liver Failure

Compassionate Treatment for End Stage Liver Disease
  • Brigid Dolan MD

Background In 2009, chronic liver disease and cirrhosis resulted in approximately 30,000 deaths, making it the twelfth leading cause of death in the United States. Patients with compensated chronic liver failure have a median survival of 12 years. After decompensation, median survival drops to ~ 2 years. This Fast Fact reviews prognosis in chronic liver failure, focusing on two validated prognostic indices. Of note, these indices predict prognosis for patients without liver transplantation.

Patients are grouped into three classes based on the total CTP score, which is simply the sum of the scores for each of the 5 variables. Patients scoring 5-6 points are considered to have Class A failure their 1 and 2 year median survivals are 95% and 90%, respectively. A score of 7-9 is considered Class B with median survivals of 80% at 1 year and 70% at two years. Class C patients have far greater mortality: 1-year median survival is 45% and 2-year is 38%. Variations in the timing and subjectivity inherent in the scoring of the CTP are its major limitations. In addition, the scale does not include renal function, an important prognostic factor in liver failure.


  • Heron M. Deaths: Leading causes for 2009. National Vital Statistics Reports 2012 61.
  • DAmico, et al. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatology. 2006 44:217231.
  • What Is Meant By Palliative Care

    Palliative care is a special supportive care intended to extend the survival time of the patients. It actively involves physical and mental support to improve the life quality, lecturing about the illness and spiritual care of the patient and their family. Drug compounding and management of pain are effective in palliative care for patients with irreversible end-stage liver diseases.

    An Innovative Liver Dialysis Machine To Help Treat Liver Failure

    The Molecular Adsorbent Recirculating System is a liver dialysis machine used in the treatment of liver failure to enable native liver regeneration. It removes protein-bound and water-soluble toxins from the blood and reduces the amounts of toxins that reach the brain. The MARS system helps prevent irreversible organ failure and improves liver regeneration and recovery. UChicago Medicine is the only center in the Chicagoland area to offer this complex medical therapy.

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    What Are The First Stages Of Cirrhosis

    First Stages Stage 1 of Cirrhosis is when your liver is inflamed and trying to heal. What your liver is going through: Your liver is destroying itself in an attempt to heal. It may show signs of swelling.

    What are the symptoms of Stage 4 liver cancer?

    You may have itchy skin, eczema, hair loss, mental confusion, high and low blood sugar swings, food coma after heavy protein meal, and swelling. Stage 4 is considered a last stage. What the liver is going through: By the time this happens, scar tissue has zig zagged through the portal vein system.

    What Organ Shuts Down First

    Prognostic Value of Hepatorenal Function By Modified Model for End ...

    The brain is the first organ to begin to break down, and other organs follow suit. Living bacteria in the body, particularly in the bowels, play a major role in this decomposition process, or putrefaction. This decay produces a very potent odor. Even within a half hour, you can smell death in the room, he says.

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    Liver Failure Complications That Affect Life Expectancy

    Cirrhosis complications have varying prognoses. For example, fluid in the abdomen, called ascites, is the most common and often the first complication of cirrhosis. After developing this, the estimated one-year survival is 50%.

    Another type of liver condition that can develop is acute-on-chronic liver failure . This occurs when someone with chronic liver failure develops multiple organ failure. A recent study found that about one-fourth of patients in the U.S. who are hospitalized for cirrhosis develop ACLF. Of these, 25% died within one month and 40% died within three months. Researchers said doctors need to recognize the seriousness of ACLF, so they can act quickly and aggressively to manage the condition.

    Exploring Goals Of Care

    Exploring patient-defined goals of care is the first step in determining the most appropriate therapeutic interventions for a specific disease or symptom. An organized approach to goal setting can help both the clinician and the patient achieve clearly articulated goals this is best accomplished through a meeting with the patient and family or surrogate decision-maker . Prior to a goal-setting meeting, the clinician should review the disease course, the patients response to prior treatments, andthe potential for further disease-modifying treatments and then develop a realistic short- and long-term vision for the future clinical course, including a general sense of prognosis. With this in mind, the clinician can begin to review treatment options and help the patient decide which treatments are most likely to help meet his or her specific goals. All therapeutic options should be examined in light of the following question:Does the treatment intervention match or assist with the patients treatment goals?6 As the burden of decision-making increases near the end of life, it is important for physicians to understand their central role in helping patients make decisions. A model of shared decision-making, in which the physician provides guidance and recommendations, is generally preferred to a paternalistic approach or, at the opposite extreme, to one in which options are presented with no guidance.7

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    Extreme Muscle Wasting And Weakness

    Patients can live with liver cirrhosis for years. However, In the late stages of liver disease, the muscle mass and muscle power significantly decrease.

    The degree of muscle wasting often reflects the severity of liver disease.

    Before death, patients with end-stage liver disease experience profound muscle wasting .

    Muscle wasting results in extreme weakness and fatigue. Patients with the end-stage liver disease before death are often unable to perform daily activities.

    What Stage Of Cirrhosis Does Ascites Occur

    Palliative Care for End Stage Liver Disease

    Ascites is the main complication of cirrhosis,3 and the mean time period to its development is approximately 10 years. Ascites is a landmark in the progression into the decompensated phase of cirrhosis and is associated with a poor prognosis and quality of life mortality is estimated to be 50% in 2 years.

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    Special Case Exemptions To Meld Score

    There is one special exemption to this method of survival prediction in chronic liver disease mentioned above. This includes a category of seriously ill patients known as status 1.Less than one percent of liver transplant patients lie in this category.

    This category includes patients who have an acute liver failure. This liver failure is sudden in onset and severe in intensity. This causes these individuals to have a life expectancy of a few hours to days if a timely transplant is not performed. Other than this all other patients who are above the age of 12 years are categorized by the MELD scoring system.

    Patients who are under the age of 12 years are categorized by another scoring system. This is known as Pediatric End-stage Liver Disease scoring system. This scoring system will use different factors according to the growth and developmental needs of the child.

    What Should I Know About Advance Care Planning

    Advance Care Planning is a process of thinking about and sharing wishes for future health and personal care. It can help prepare everyone when a person becomes ill and unable to communicate. ACP takes into account goals, values, and beliefs with regard to a persons end-of-life decisions. The process of planning involves the patient, their family, and their health care team, and it can help guide future health care decisions. The discussion should begin early in the disease process to ensure a plan is in place for managing the patient when their health declines. ACP directives should be reviewed, especially during hospital admissions.

    Some topics to think about can include:

    • What is important to you?
    • Do you have beliefs that influence your health care wishes?
    • Are there conditions under which you do or do not want a certain treatment?
    • Where would you want to be cared for?
    • Have you had experiences with family or friends where health care decisions had to be made?
    • Have you considered Organ and Tissue Donation?

    Some documents that should be considered:

    Power of Attorney: Legal document that gives another person the right to make medical decisions on the patients behalf

    Living will: Document that details the patients preferences for future medical care, usually consisting of resuscitation and life support preferences and specific interventions, such as enteral feeding or ventilator support

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    How Hospice Can Help Patients With End

    When a patient meets end-stage liver disease hospice eligibility requirements, including a life expectancy of six months or less if the disease follows its typical path, they may begin hospice care. As soon as the patient is admitted to hospice care, a team of hospice professionals will swing into action to provide care wherever the patient resides including their home, a nursing home, or an assisted living facility.

    The hospice team includes a medical director, nurse, aide, social worker, chaplain, bereavement counselors and volunteers who focus on providing the patient with the highest possible quality of life for as long as the patient has. This includes providing all medication, medical equipment, and medical supplies necessary for treatment of the patients hospice diagnosis at no cost to the patient or family.

    This whole-patient care is designed to support the patient’s physical, emotional, and spiritual needs.

    To learn more about how Crossroads Hospice & Palliative Care supports patients with liver disease, please call 1-888-564-3405.

    End Stage Liver Disease Life Expectancy

    End Stage Liver Failure Symptoms, Diagnosis, Treatments and Causes ...

    End stage liver disease life expectancy may not stir within one much hope, since functions of the body start to go haywire from the liver’s deterioration. Find out more on what the symptoms are at this point, and what diet is most suitable…

    End stage liver disease life expectancy may not stir within one much hope, since functions of the body start to go haywire from the livers deterioration. Find out more on what the symptoms are at this point, and what diet is most suitable

    The liver is an organ that plays a very important role when it comes to the different functions of the body. It weighs roughly 3 pounds and is considered the largest organ in mass in the body. Liver disease or what is scientifically known as liver cirrhosis, is when the liver is infected to a degree where the balance of functionality in the body is lost.

    It is a slowly advancing disease, where liver tissue is converted to what is called scar tissue, ultimately obstructing the livers ability to function efficiently. The life expectancy during this stage is said to be about 6 months after liver failure.

    During liver disease, blood is blocked by scar tissue, where drugs, hormones, toxins that the body needs to produce and nutrients are affected. Proteins are another important component that the body requires, which the liver slows down in terms of production, ultimately ceasing to do so completely.

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    What Treatments Are Available For Liver Failure

    Patients with acute-on-chronic liver failure may see their livers fail over weeks to months, compared to months to years as is typical in chronic liver failure.

    As with acute liver failure, we focus first on treating the underlying cause of sudden liver failure before considering a possible liver transplant.

    In many cases, the only treatment for liver failure is a liver transplant. However, liver failure is sometimes brought on by an acute or hereditary cause that can be treated. For instance, when liver failure is caused by ingesting too much acetaminophen , we will use medicine to counteract the effects of this common drug to reduce liver damage. When liver failure results from a hereditary copper-overload disease, we will use medications to remove the copper out of the body. Or when liver failure is precipitated by an infection in patients with cirrhosis, we will use antibacterial medicines to fight the infection to, hopefully, return the liver to its previous functional state.

    Early Allograft Dysfunction Discovery And Prognosis: Does The Model For End

    Yong-Fa Huang1,2#, Jing-Yi Liu1,2,3#, Li-Ying Sun1,2,3, Zhi-Jun Zhu1,2

    1 Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital , Clinical Center for Pediatric Liver Transplantation , Department of Critical Liver Diseases, Liver Research Center, Beijing Friendship Hospital , China

    #These authors contributed equally to this work.

    Correspondence to:

    Submitted Jun 20, 2022. Accepted for publication Sep 01, 2022.

    doi: 10.21037/apm-22-758

    We read with great interest in the article by Luo et al. about comparison among Olthoff criteria, the Model for End-stage Liver Disease score on postoperative day 5 , and the Model for Early Allograft Function scoring on their prognostic value for post-transplant graft and patient survival . Though all three metrics discriminated the high-risk patients from others effectively, MELDPOD5 displayed quite an advantage over MEAF and Olthoff criteria in predicting 3-month graft survival. Moreover, donor body mass index, donor risk index, intraoperative transfusions, recipient hypertension, and preoperative total bilirubin were identified as predictive factors for MELDPOD5-defined early allograft dysfunction .

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    When Cirrhosis Liver Is In Final Stage

    Asked by: Larue Von

    When liver damage progresses to an advanced stage, fluid collects in the legs, called edema, and in the abdomen, called ascites. Ascites can lead to bacterial peritonitis, a serious infection. When the liver slows or stops producing the proteins needed for blood clotting, a person will bruise or bleed easily.

    Advance Care Planning/social Support

    End Stage Liver Disease

    While data are scarce, goals of care and advance care planning seem to be discussed less frequently with ESLD patients compared with cancer patients. In SUPPORT, 66% of ESLD patients preferred cardiopulmonary resuscitation when asked about resuscitation status.9,48 In a separate study conducted at three teaching hospitals, 16% of ESLD patients had DNR orders compared with 47% of patients with metastatic lung cancer. Housestaff were less likely to discuss these issues with ESLD patients despite awareness of their poor prognosis.49 There is an inherent difficulty in discussing advance directives with patients pursuing curative therapies and DNR orders are often considered controversial for patients awaiting transplantation. Bramstedt,50 a transplant ethicist, argues that in certain patients with ESLD, resuscitation may be futile and not in a seriously ill patient’s best interest. It is imperative to discuss goals of care and identify health care proxy agents promptly, as encephalopathy can impact decision making.

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    Liver Disease Symptoms And Treatmenthow Palliative Care Can Help

    Liver failure signs and symptoms include fatigue , jaundice , swelling of the legs and abdomen, appetite loss and weight loss, nausea, itchy skin and hiccups.

    Fluids that build up in your body can be treated with medications and nondrug treatments. Your palliative care team will know the right medicines to give you to help relieve common symptoms such as shortness of breath, itchy skin, nausea and hiccups.

    Over time, cirrhosis can get worse, and your liver may no longer work properly. This chronic liver failure is called end-stage liver disease, when symptoms may become more severe. Your palliative care team will help you and your family to deal with these symptoms.

    If youre eligible for a liver transplant, you can turn to palliative care for symptom control and emotional support before, during and after surgery. Your palliative care team will work alongside your doctor and transplant team to support you and your family every step of the way.

    it is best to bring in the palliative care team after diagnosis. The team will treat your symptoms, explain your treatment choices and help you to match those options to your personal goals. The team specialists will also help you better understand your condition and what to expect. They always work in partnership with your other doctors.

    The team will also help your family caregivers. They will help you and your loved ones make both large and small decisions.

    These are some of the many benefits of palliative care.

    Hepatocyte Or Stem Cell Transplantation

    Based on several successful survival studies in large animals , cell transplantation has been studied as an alternative way of filling the treatment gap at the ICU for ESLF patients .

    Initially, hepatocytes were the cell source of choice for cell transplantation of ESLF patients. Five patients with ALF underwent intrasplenic or/and intrahepatic hepatocyte transplantation. All patients showed temporary clinical and biochemical improvement but eventually died . A severe complication is that for treatment of ESLF large amounts of successfully engrafting and safe hepatocytes are needed. Therefore, hepatocyte transplantation is a more promising strategy for correcting liver-based metabolic deficiencies , requiring lower amounts of engrafted cells, and is less suitable for ESLF therapy.

    Besides hepatocytes, mesenchymal stem cells have also been applied in cell transplantations in preclinical survival studies in large animals . These cells do not directly support liver functions, but rather produce paracrine factors with immunomodulatory and liver regeneration promoting effects .

    A controlled study in HBV-associated ACLF patients compared the outcomes of four groups: controls : PE , umbilical cord-MSC transplantation and UC-MSC+PE . It was concluded that MSC transplantation combined with PE treatment was safe, but could not significantly improve the short-term prognosis of HBV-ACLF patients compared to the single treatment.

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    Lost Appetite Nausea Or Vomiting

    In the very advanced stages of end-stage liver disease, patients may completely stop eating too little amounts.

    Also, constant nausea and repeated vomiting are frequent end-stage liver symptoms before death.

    Consult your doctor if you have a relative with liver cirrhosis that developed a complete loss of appetite and decreased intake.

    These gastrointestinal symptoms often occur together with other signs of liver deterioration, such as worsening jaundice and ascites.

    Anorexia and vomiting are often a reflection of advanced liver complications such as:

    • Acute on top chronic of liver failure.
    • Advancement of liver cancer into a late stage.
    • Deterioration of the liver function due to any other causes.

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